It was along the Mississippi River _________ Mark Twain spent much of his childhood.

how

which

that

where

此处构成It was...that...强调句式，句中强调了介词短语along the Mississippi River。故选C。

In our daily life, everyone fails every now and then. It is how you             that makes a difference.

react

replace

rely

request

考查动词词义辨析。句意：在我们的日常生活中，每个人都会时不时地失败，你对失败如何反应才是关键。A. react反应；B. repalce取代，代替；C. rely 依靠，依赖；D.request要求；根据“n our daily life, everyone fails every now and then”，应是“怎样做出反应”。故选A项。

          no bus,we had to walk home.

There was

There being

Because there being

It being

考查独立主格结构。句意：没有车，我不得不走路回家。根据句意，表示“存在”，要用there be 句型；分析句子可知，设空处应用非谓语动词，there be只有主动形式，故用现在分词；因为非谓语动词有自己独立的的主语no bus,所以此处是独立主格结构。故选B项。