The programme can't be             him because it is beyond his ability.

charged with

in charge of

taken charge of

in the charge of

考查固定短语辨析。句意：这个项目不可能由他负责，因为它超出了他的能力。A. charged with控告；B. in charge of负责，主管；C. taken charge of 接管，负责；D. in the charge of 由......负责。根据because it is beyond his ability及空格后him可知用in the charge of 符合题意。故选D项。

---I think you are different now.

---Of course，times have changed and________.

so have I

so I have

neither have I

neither I have

肯定的陈述句后，跟so+主语+谓语，表示强调：确实…，其主语与前陈述句的主语相同；肯定的陈述句后，跟so+谓语+主语，表示…也…，其主语与前陈述句的主语不同．根据times have changed，可知对另一个"我"说时代也已经变了，用倒装句，本句是现在完成时，含有助动词have，主语为I，在这里还用助动词have完成，故选A．

Perhaps they have experienced something similar and do not want you to           the same pain.

go over

go through

go around

go on

考查动词短语辨析。句意：也许他们有过类似的经历，不希望你经历同样的痛苦。A. go over复习，重温；B. go through经受，通过；C. go around 四处走动，流传；D. go on继续。根据the same pain可知，此处是“经历，经受”的意思。故选B项。

While we may not be born with a nature talent, we can          for it with hard work.

break up

take up

bring up

make up

考查动词短语辨析。句意：虽然我们可能没有与生俱来的天赋，但我们可以通过努力工作来弥补。A. break up打碎；B.take up 拿起，开始从事；C.bring up提出；D. make up 弥补。根据上文we may not be born with a nature talent可知没有与生俱来的天赋，所以要通过努力工作来弥补。故选D项。

it was at 10 pm yesterday______he came home from work.

that

when

which

what

考查强调句。句意：昨天晚上10点他下班回家。考查it+be+强调部分+that+句子，选A。