charged with

in charge of

taken charge of

in the charge of

考查固定短语辨析。句意：这个项目不可能由他负责，因为它超出了他的能力。A. charged with控告；B. in charge of负责，主管；C. taken charge of 接管，负责；D. in the charge of 由......负责。根据because it is beyond his ability及空格后him可知用in the charge of 符合题意。故选D项。

how

which

that

where

此处构成It was...that...强调句式，句中强调了介词短语along the Mississippi River。故选C。

the time

when

that

which

强调句的结构是：It＋be＋强调部分＋that(who)＋主谓句。强调句的连词只有两个，that和who。当强调的部分是人，且为句子的主语时，才用“who”，其余用that。因此选C。

to

for

as

by

考查介词词义辨析。句意：让我们学会把我们所面对的问题作为通向未来成功的手段来利用。A.to朝，对 ；B.for 为了，对于；C.as 作为；D.by通过，凭借。根据句意可知，此处“作为”符合语境。故选C项。